|
KMID : 0356620150300030395
|
|
Journal of Korean Society of Endocrinology
2015 Volume.30 No. 3 p.395 ~ p.401
|
|
|
Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation
|
|
:Lee Hyae-Min
:Lee Sun-Hee/:Yang In-Ho/:Hwang In-Kyoung/:Hwang You-Cheol/:Ahn Kyu-Jeung/:Chung Ho-Yeon/:Hwang Hui-Jeong/:Jeong In-Kyung
|
|
|
Abstract
|
|
|
|
The leading cause of morbidity and mortality in patients with acromegaly is cardiovascular complications. Myocardial exposure to excessive growth hormone can cause ventricular hypertrophy, hypertension, arrhythmia, and diastolic dysfunction. However, congestive heart failure as a result of systolic dysfunction is observed only rarely in patients with acromegaly. Most cases of acromegaly exhibit high levels of serum insulin-like growth factor-1 (IGF-1). Acromegaly with normal IGF-1 levels is rare and difficult to diagnose. Here, we report a rare case of an acromegalic patient whose first clinical manifestation was severe congestive heart failure, despite normal IGF-1 levels. We diagnosed acromegaly using a glucose-loading growth hormone suppression test. Cardiac function and myocardial hypertrophy improved 6 months after transsphenoidal resection of a pituitary adenoma.
|
|
|
KEYWORD
|
|
|
Acromegaly, Heart failure, Insulin-like growth factor I
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|